Mitomycin 10 mg for intravenous injection KOCAK, Turkey
Compound
active ingredient: mitomycin;
1 bottle contains 2 mg, 10 mg or 20 mg of mitomycin;
excipients: sodium chloride.
Dosage form
Powder for solution for injection.
Pharmacological group
Antitumor antibiotics. ATC code L01D C03.
testimony
Reduction of subjective and objective symptoms associated with such diseases: chronic lymphatic leukemia, chronic myelogenous leukemia, stomach cancer, colorectal cancer, lung cancer, pancreas, liver, cervix, endometrium, breast, head and neck, bladder.
Contraindications
Hypersensitivity to mitomycin. Thrombocytopenia, bleeding disorders and increased bleeding. During pregnancy and breastfeeding.
Dosage and administration
Apply to adults in the conditions of specialized medical institutions. The dose and duration of treatment are set individually, depending on the severity of the disease, the condition and age of the patient.
Periodic application.
Usually administered intravenously 4 - 6 mg mitomycin C Kiovo 1 - 2 times a week.
Consistent application.
Usually administered intravenously 2 mg mitomycin C Kiovo 1 time per day.
Periodic use of a large dose.
Usually administered intravenously 10 - 30 mg mitomycin C Kiovo 1 - 3 (or more) times a week.
Simultaneous use with other antineoplastic agents.
Usually, 2-4 mg of mitomycin C Kiovo are used 1-2 times a week in combination with other antineoplastic agents.
Preparation of solution for injection.
The drug is dissolved directly in a vial in a ratio of 5 ml of distilled water for injection of 2 mg of mitomycin C Kiovo. Administered as a slow injection.
Bladder cancer.
Usually, 4-10 mg of mitomycin C Kiovo in the bladder daily or every 2 days is prescribed to prevent relapses. With a therapeutic purpose, 10-40 mg of mitomycin C is administered into the urinary mukhir 1 time per day. The dose may be adjusted according to the patient's age and severity of symptoms.
If necessary, Mitomycin C Kiovo can also be used intra-arterially, intramedullary, intrapleurally and intraperitoneally at a dosage of 2-10 mg daily. The dose may be divided according to the age of the patient and the severity of the symptoms.
adverse reactions
Hematological complications: leukopenia, thrombocytopenia, hemorrhages, anemia (rarely - microangiopathic hemolytic anemia).
Liver: rarely - impaired liver function. Kidneys: hemolytic uremic syndrome or proteinuria, hematuria, edema. Gastrointestinal: anorexia, nausea and vomiting, stomatitis.
Allergic reactions: rash.
Urinary system: cystitis, hematuria or bladder atrophy caused by bladder instillation therapy. Respiratory system: interstitial pneumonia and pulmonary fibrosis.
Others: rarely - symptoms of malaise, alopecia.
Overdose
Possible increased side effects. Treatment is symptomatic.
Use during pregnancy and lactation
During pregnancy, the drug is contraindicated, since there are reports of a possible embryotoxic effect of mitomycin.
During the period of treatment should stop breastfeeding.
Children
Children are not prescribed the drug.
Special Security Measures
Under the constant supervision of a physician, the drug is used in patients:
- with impaired liver function;
- with impaired renal function;
- with oppression of bone marrow hematopoiesis;
- with disorders caused by infectious diseases
- with chickenpox (deadly complications may occur).
Application features
The drug is used in specialized medical institutions. The introduction should be carried out with caution to prevent extravasation of the drug causing sclerosis or tissue necrosis.
To avoid angialgia, phlebitis and thrombosis, the administration of the drug should be carried out as slowly as possible, paying careful attention to the choice of the site and method of injection.
Mitomycin C Kiovo is incompatible with low pH during the preparation of the drug solution.
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Commercial name:Mitomycin
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Dosage:20 mg
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Quantity:one
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Release form:Bottle
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Производитель:Индия
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